Unfortunately, the information on the use of excessive dose anabolic steroids in humans are mainly supplied as case reports or small studies that lack adequate management teams. In addition, the info out there within the literature does not account for the steroid type or dose, as neither may be identified. Patients also may be taking concomitant stimulants, similar to ephedra, which might confound information and the potential for opposed events. It is likely that the frequency of cardiac events is underreported in the medical literature. Supraphysiologic doses of anabolic-androgenic steroids , which embody greater than 30 natural and synthetic derivatives of testosterone, may trigger a wide spectrum of medical sequalae.
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- Anabolic androgenic steroid use has increased over the past decade, regardless of its potential for antagonistic results.
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We report a case of an acute ST-segment elevation myocardial infarction in a patient with conventional cardiac threat components utilizing supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this patient also had polycythemia, probably secondary to high-dose testosterone. The affected person underwent profitable percutaneous intervention of the proper coronary artery. Physicians and patients ought to concentrate on the clinical consequences of anabolic steroid abuse.
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Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a component of endothelial dysfunction has been proposed, which can contribute to irregular vessel reactivity. However, testosterone in physiologic doses might even be helpful in sufferers with angina , have larger ischemic thresholds and improved quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and will increase coronary blood circulate in men with established coronary artery illness .
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