We report a case of an acute ST-segment elevation myocardial infarction in a affected person with conventional cardiac threat components utilizing supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this patient additionally had polycythemia, likely secondary to high-dose testosterone. The affected person underwent successful percutaneous intervention of the proper coronary artery. Physicians and patients should concentrate on the scientific penalties of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996).
- Rhoden EL, Morgentaler A. Risks of testosterone-replacement therapy and proposals for monitoring.
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Erythrocytosis has been reported as a potential effect of testosterone, which can be useful in sufferers with anemia. The biggest threat of erythrocytosis occurs with injectable forms of testosterone compared with transdermal preparations, especially in supraphysiologic doses. An improve of as a lot as 44% of the baseline hematocrit has been reported .
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Rhoden EL, Morgentaler A. Risks of testosterone-replacement therapy and recommendations for monitoring. Testosterone substitute in hypogonadal males with angina improves ischaemic threshold and quality of life. Ajayi AAL, Mathur R, Halushka PV. Testosterone improve human platelet thromboxane A2 receptor density and aggregation responses.
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